目的 研究齿瓣石斛的化学成分。方法 应用硅胶、凝胶和制备液相层析等方法分离得到单体化合物,通过理化常数和波谱分析鉴定化合物的结构。结果 从齿瓣石斛体积分数95%乙醇提取物中分离得到25个化合物,分别鉴定为3-羟基-4′,5-二甲氧基联苄(1),3,4′,5-三羟基-3′-甲氧基联苄(2),3,4′,5-三羟基联苄(3),N-反式-香豆酰酪胺(4), N-反式-对羟基苯乙基咖啡酰胺(5), 对羟基苯丙酰酪胺(6),N-顺式-香豆酰酪胺(7), 2,5-二羟基-4-甲氧基-9,10-二氢菲(8),2,4,7-三羟基-9,10-二氢菲(9),柚皮素(10),二氢松柏醇乙酸酯(11),对羟基桂皮酸乙酯(12),对羟基桂皮酸(13),对羟基苯丙酸(14),对羟基苯甲酸(15),原儿茶酸(16),erigeside Ⅱ(17),枸橼苦素(18),二氢丁香苷(19),leonuriside A(20),腺苷(21),β-谷甾醇(22),胡萝卜苷(23),(+)-丁香脂素-O-β-D-吡喃葡萄糖苷(24),蔗糖(25)。结论 化合物1~21,24~25均为首次从齿瓣石斛中分离得到,其中,化合物1为首次从石斛属植物中分得,化合物5、7、11、12、18为首次从兰科植物中分得。
Abstract
OBJECTIVE To study the chemical constituents of Dendrobium devonianum. METHODS The compounds were isolated and purified by means of column chromatography with silica gel, Sephadex LH-20 and prep- HPLC. Their structures were identified on the basis of physicochemical parameters and spectroscopic data comparison with standard literature data. RESULTS Twenty-five compounds were isolated from the 95% ethanol extract of D. devonianum, and identified as 3-hydroxy-4′,5-dimethoxybibenzyl(1), tristin(2), 3,4′,5-trihydroxybibenzyl(3), N-trans-coumaroyltyramine(4), N-trans- caffeoyltyramine(5), p-hydroxyphenylpropionyltyramine(6), N-cis-coumaroyltyramine(7), 2,5-dihydroxy-4-methoxy-9, 10-dihydrophenanthrene(8), 2,4,7-trihydroxy-9,10-dihydrophenanthrene(9), 4′,5,7-trihydroxy-flavonol(10), dihydroconifery acetate(11), ethyl 4-hydroxycinnamate(12), p-hydroxycinnamic acid(13), p-hydroxyphenylpropionic acid(14), 4-hydroxybenzoic acid(15), protocatechuic acid(16), erigeside Ⅱ(17), citrusin C(18), dihydrosyringin(19), leonuriside A(20), adenosine(21), β-sitosterol(22), daucosterol(23),(+)-syringgaresinol-O-β-D-glucopyranoside(24) and sucrose(25). CONCLUSION Compounds 1-21 and 24-25 are obtained from this plant for the first time. Compound 1 is isolated from the Dendrobium genus for the first time. Compounds 5, 7, 11, 12 and 18 are obtained from Orchidaceae for the first time.
关键词
齿瓣石斛 /
化学成分 /
芪类化合物 /
酰胺类 /
二氢黄酮类 /
酚酸类 /
苯丙素类
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Key words
Dendrobium devonianum /
chemical constituent /
stilbene /
amide /
dihydroflavone /
phenolic acid /
phenylpropanoid
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中图分类号：
R284
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参考文献
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脚注
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基金
国家自然科学基金资金项目(31100265,31070300)
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